Current alcohol consumption was associated with a reduced risk of ALS (incident patient group: odds ratio = 0.52, 95% CI: 0.40, 0.75). Cox regression models showed that current smoking was also independently associated with shorter survival (hazard ratio = 1.51, 95% CI: 1.07, 2.15), explaining the lack of association in the prevalent and referral patient groups. Multivariate analyses showed an increased risk of ALS among current smokers (odds ratio = 1.38, 95% confidence interval (CI): 1.02, 1.88) in the incident patient group only. ![]() ![]() To prove the relevance of population-based incidence cohorts in case-control studies, the authors compared results with those from cohorts including patients with prevalent ALS and referral patients. The authors performed a population-based case-control study in the Netherlands between 20, including 494 patients with incident ALS and 1,599 controls. Smoking has been posited as a possible risk factor for amyotrophic lateral sclerosis (ALS), but large population-based studies of patients with incident disease are still needed. Smoking, alcohol consumption, and the risk of amyotrophic lateral sclerosis: A population-based study. Critique 087: Smoking increases, while alcohol consumption may decrease, the risk of amyotrophic lateral sclerosis (ALS) - 8 August 2012ĭe Jong SW, Huisman MHB, Sutedja NA, van der Kooi, AJ, de Visser M, Schelhaas HJ, Fischer K, Veldink JH, van den Berg LH.
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